Research Opportunities utilizing data from the AHA COVID-19 CVD Registry
随着冠状病毒大流行的严重性开始在美国显现出来, 美国心脏协会的“遵循指南”(GWTG)质量改进项目迅速采取了行动. In a matter of weeks, 将针对covid -19的特定数据元素添加到现有的GWTG Registry中风模块中, heart failure, atrial fibrillation, coronary artery disease, and resuscitation. 早期报告描述了COVID-19与现有心血管疾病(CVD)或CVD危险因素患者的显著不良心血管结局和严重并发症的关联,强调了迫切需要进一步研究.
The AHA responded by launching the multicenter COVID-19 CVD Registry, powered by Get With The Guidelines, in April 2020. This registry collects biomarkers, clinical data, and cardiovascular outcomes in COVID-19 patients, 允许参与站点实时审查数据,并为数据库提供资料,以研究未来几年大流行的影响. 健壮的GWTG注册中心基础设施支持快速数据收集, including over 28,000 patient records and nearly 130,000 lab reports, with more than 150 registry sites enrolled .
“研究是追踪治疗效果和患者预后模式的关键. 访问这个快速增长的数据集为多个团队提供了在多个方面同时取得突破的潜力,” explains James de Lemos, M.D., 登记指导委员会的联合主席医学教授和甜心球克恩·威尔登塔尔, M.D., Ph.D.他是达拉斯德克萨斯大学西南医学中心心脏病学特聘教授. “这有助于帮助医疗保健专业人员收集快速调整COVID-19患者方案所需的证据,并反映了美国心脏协会COVID-19心血管疾病登记处的重要性.”
As a quality improvement program, investigator-led research opportunities using the aggregate, 国家数据集最初提供给参与登记处的机构的调查人员. 这些早期研究已经为临床实践提供了可靠的数据来源,以潜在地改善患者的预后. Late-breaking advances were presented at AHA’s Scientific Sessions, 描述来自登记的初步结果,包括治疗和结局的种族和民族差异,以及COVID-19患者体重指数与心血管结局的相关性. 另外几项研究将在未来几周和几个月内发表在同行评议文献中.
美国心脏协会现在很高兴向更广泛的研究界提供COVID-19心血管疾病登记处的研究机会, regardless of registry participation. 提案以滚动方式接受,并将按优先顺序进行评估, novel contribution to the scientific literature, feasibility with the data collected, and merit.
Several high-quality studies have been published using these data. 这些研究极大地促进了我们对如何最好地照顾因COVID住院的患者的集体知识, including patients with comorbidities, vulnerable patient populations at greater risk of poor health outcomes, and in-hospital quality of care for patients with COVID. Find these publications at the Quality Improvement Publications Library.
Proposal and review process:
- Note: The registry is no longer collecting data as of Summer 2022.
- Prior to drafting and submitting a research proposal, please review the data elements collected in the COVID-19 CVD Registry's Case Report Form (CRF) 确保根据登记处收集的数据进行研究分析的可行性.
- Download and complete a COVID-19 CVD Registry Proposal Form
- Submit the proposal to the American Heart Association at [email protected]
- 提案将由美国心脏协会COVID-19研究与出版物(R&P) Committee and will be evaluated on priority, novel contribution to the scientific literature, feasibility with the data collected, and merit.
- Each approved project will be assigned a liaison from the R&P Committee to support the project from proposal to publication.
在与美国心脏协会的努力,加快研究影响和精简研究合作对齐, this data will be made available on the AHA Precision Medicine Platform (PMP). This cloud-computing platform, hosted by the AHA Institute for Precision Cardiovascular Medicine, 提供安全的工作空间配备了最先进的分析工具.
- 建议的分析应在获得精准医疗平台数据后四周内完成.
- 拥有基于web的SAS许可或熟悉其他编程语言的研究人员可以在精准医疗平台上的安全工作空间中进行经批准的分析.
- 研究人员也可以联系美国心脏协会数据科学家,他们提供咨询数据分析服务,在精准医疗平台上进行经批准的统计分析.
在完成对COVID-19 CVD Registry数据的建议分析后, researchers will draft the findings for a peer-reviewed manuscript.
- 该研究的第一作者将在将手稿提交指导委员会和美国心脏协会科学的最终批准之前获得所有共同作者的批准.
- 手稿应在获得精准医学平台数据的八周内起草并提交指导委员会批准.
注:未经AHA COVID-19指导委员会的提案审查和美国心脏协会的书面批准,不得使用COVID-19心血管疾病登记处进行未经授权的数据分析. 所有出版物必须遵循美国心脏协会的质量改进计划出版指南. More information is available at 8b5bx.web-sitemap.slbprod.net/qualityresearch.